use cases

Logo

In this repo, we present a full example of the metaGOflow pipeline using actual EMO BON sequence data.

View the Project on GitHub hariszaf/metaGOflow-use-case

Marine sediment

Quality control

metaGOflow invokes fastp that automatically returns a .html report like the one below for the case of this marine sediment sample:

Taxonomic inventory

metaGOflow uses the mapSEQ to extract taxa present on the community based on the ribosomal RNA sequences.

Here is the krona plot metaGOflow returns as a visual component of the community structure.

Functional annotation

metaGOflow supports a functional annotation step that uses the filtered reads and a series of tools and databases to return several types of annotations.

InterProScan (IPS)

On the first column we get the number of hits an id had among the reads, on the second the IPS id and on the third its description.

115018 IPR003439 ABC transporter-like, ATP-binding domain
111468 IPR001789 Signal transduction response regulator, receiver domain
73852 IPR000917 Sulfatase, N-terminal
71296 IPR001036 Acriflavin resistance protein
65050 IPR000719 Protein kinase domain
59116 IPR015590 Aldehyde dehydrogenase domain
54482 IPR002347 Short-chain dehydrogenase/reductase SDR
53966 IPR000873 AMP-dependent synthetase/ligase
49167 IPR002078 RNA polymerase sigma factor 54 interaction domain
47369 IPR000160 GGDEF domain
45726 IPR019734 Tetratricopeptide repeat
45391 IPR003594 Histidine kinase/HSP90-like ATPase
43947 IPR013517 FG-GAP repeat
40889 IPR001633 EAL domain
39522 IPR010869 Protein of unknown function DUF1501
38792 IPR000515 ABC transporter type 1, transmembrane domain MetI-like
34853 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
32564 IPR020846 Major facilitator superfamily domain
31968 IPR005467 Histidine kinase domain
31267 IPR004839 Aminotransferase, class I/classII
26670 IPR003959 ATPase, AAA-type, core
26520 IPR000847 Transcription regulator HTH, LysR
26211 IPR005814 Aminotransferase class-III
25372 IPR001482 Type II/IV secretion system protein
25170 IPR000014 PAS domain
24693 IPR001173 Glycosyltransferase 2-like
24069 IPR001753 Enoyl-CoA hydratase/isomerase
24026 IPR000795 Translational (tr)-type GTP-binding domain
24012 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
23650 IPR001434 Large cysteine-rich periplasmic protein OmcB-like, DUF11 domain
23324 IPR002300 Aminoacyl-tRNA synthetase, class Ia
22866 IPR000182 GNAT domain
22533 IPR000644 CBS domain
22485 IPR000192 Aminotransferase class V domain
22307 IPR001509 NAD-dependent epimerase/dehydratase
21698 IPR007627 RNA polymerase sigma-70 region 2
21628 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
21500 IPR010221 VCBS repeat
21452 IPR013126 Heat shock protein 70 family
21086 IPR001734 Sodium/solute symporter
21071 IPR017932 Glutamine amidotransferase type 2 domain
21051 IPR001867 OmpR/PhoB-type DNA-binding domain
21018 IPR005119 LysR, substrate-binding
20979 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
20440 IPR011527 ABC transporter type 1, transmembrane domain
20355 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
20188 IPR011659 WD40-like beta propeller
19818 IPR010656 TRAP C4-dicarboxylate transport system permease DctM subunit
19648 IPR001680 WD40 repeat
19178 IPR006665 OmpA-like domain
19175 IPR003673 CoA-transferase family III
19033 IPR001650 Helicase, C-terminal
18783 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit
18745 IPR011444 Domain of unknown function DUF1549
18661 IPR023753 FAD/NAD(P)-binding domain
18449 IPR006680 Amidohydrolase-related
18266 IPR022655 Domain of unknown function DUF1553
18130 IPR040853 RapA2, cadherin-like domain
18015 IPR022028 Protein of unknown function DUF3604
18007 IPR011545 DEAD/DEAH box helicase domain
17898 IPR014001 Helicase superfamily 1/2, ATP-binding domain
17621 IPR018060 DNA binding HTH domain, AraC-type
17618 IPR006656 Molybdopterin oxidoreductase
17449 IPR002372 Pyrrolo-quinoline quinone repeat
17375 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain
17161 IPR011251 Luciferase-like domain
17143 IPR002104 Integrase, catalytic domain
17027 IPR018247 EF-Hand 1, calcium-binding site
16908 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase
16492 IPR016040 NAD(P)-binding domain
16408 IPR001279 Metallo-beta-lactamase
16388 IPR001296 Glycosyl transferase, family 1
16353 IPR001926 Pyridoxal-phosphate dependent enzyme
16246 IPR009056 Cytochrome c-like domain
16226 IPR000883 Cytochrome c oxidase subunit I
16173 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
15763 IPR001584 Integrase, catalytic core
15715 IPR001763 Rhodanese-like domain
15708 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
15665 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
15551 IPR020616 Thiolase, N-terminal
15375 IPR001466 Beta-lactamase-related
15270 IPR034733 Acetyl-CoA carboxylase
15259 IPR041690 Cadherin-like domain
15190 IPR008271 Serine/threonine-protein kinase, active site
15169 IPR003660 HAMP domain
15074 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
15062 IPR017926 Glutamine amidotransferase
14979 IPR014030 Beta-ketoacyl synthase, N-terminal
14786 IPR014018 SecA motor DEAD
14563 IPR001343 RTX calcium-binding nonapeptide repeat
14438 IPR012902 Prokaryotic N-terminal methylation site
14208 IPR003029 S1 domain
14106 IPR006076 FAD dependent oxidoreductase
14091 IPR000073 Alpha/beta hydrolase fold-1
13853 IPR001647 DNA-binding HTH domain, TetR-type
13797 IPR003423 Outer membrane efflux protein
13597 IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)
13588 IPR003010 Carbon-nitrogen hydrolase
13559 IPR005835 Nucleotidyl transferase domain
13394 IPR013216 Methyltransferase type 11
13325 IPR012910 TonB-dependent receptor, plug domain
13238 IPR028971 NAD-glutamate dehydrogenase
13132 IPR006073 GTP binding domain
13063 IPR006099 Methylmalonyl-CoA mutase, alpha/beta chain, catalytic
13043 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
12954 IPR023210 NADP-dependent oxidoreductase domain
12951 IPR006685 Mechanosensitive ion channel MscS
12873 IPR013249 RNA polymerase sigma factor 70, region 4 type 2
12863 IPR000209 Peptidase S8/S53 domain
12783 IPR005532 Sulfatase-modifying factor enzyme
12764 IPR000914 Solute-binding protein family 5 domain
12641 IPR000700 PAS-associated, C-terminal
12624 IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
12572 IPR005475 Transketolase-like, pyrimidine-binding domain
12517 IPR002932 Glutamate synthase domain
12498 IPR000531 TonB-dependent receptor-like, beta-barrel
12495 IPR025110 AMP-binding enzyme, C-terminal domain
12491 IPR003838 ABC3 transporter permease protein domain
12476 IPR001460 Penicillin-binding protein, transpeptidase
12404 IPR006222 Aminomethyltransferase, folate-binding domain
12238 IPR007197 Radical SAM
12230 IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
12225 IPR001991 Sodium:dicarboxylate symporter
12215 IPR000683 Gfo/Idh/MocA-like oxidoreductase, N-terminal
12193 IPR000595 Cyclic nucleotide-binding domain
12167 IPR020845 AMP-binding, conserved site
12165 IPR001463 Sodium:alanine symporter
12022 IPR037523 Vicinal oxygen chelate (VOC) domain
11936 IPR022761 Fumarate lyase, N-terminal
11855 IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
11846 IPR023631 Amidase signature domain
11778 IPR002528 Multi antimicrobial extrusion protein
11764 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding
11689 IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
11630 IPR001986 Enolpyruvate transferase domain
11572 IPR014016 UvrD-like helicase, ATP-binding domain
11548 IPR011701 Major facilitator superfamily
11519 IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
11494 IPR037522 HD-GYP domain
11327 IPR023616 Cytochrome c oxidase-like, subunit I domain
11294 IPR008146 Glutamine synthetase, catalytic domain
11212 IPR001962 Asparagine synthase
11168 IPR000788 Ribonucleotide reductase large subunit, C-terminal
11164 IPR024084 Isopropylmalate dehydrogenase-like domain
11145 IPR000060 BCCT transporter family
11139 IPR000581 Dihydroxy-acid/6-phosphogluconate dehydratase
11074 IPR020904 Short-chain dehydrogenase/reductase, conserved site
10977 IPR006016 UspA
10969 IPR000792 Transcription regulator LuxR, C-terminal
10924 IPR000994 Peptidase M24
10702 IPR002020 Citrate synthase
10588 IPR024607 Sulfatase, conserved site
10554 IPR001048 Aspartate/glutamate/uridylate kinase
10506 IPR002205 DNA topoisomerase, type IIA, domain A
10412 IPR000121 PEP-utilising enzyme, C-terminal
10400 IPR013154 Alcohol dehydrogenase, N-terminal
10395 IPR011703 ATPase, AAA-3
10354 IPR017441 Protein kinase, ATP binding site
10330 IPR001017 Dehydrogenase, E1 component
10313 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain
10295 IPR006153 Cation/H+ exchanger
10293 IPR018076 Type II secretion system protein GspF domain
10281 IPR018389 TRAP transporter solute receptor DctP
10203 IPR000089 Biotin/lipoyl attachment
10150 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
10142 IPR000620 EamA domain
10127 IPR006311 Twin-arginine translocation pathway, signal sequence
10111 IPR011547 SLC26A/SulP transporter domain
10103 IPR001851 ABC transporter, permease
10102 IPR000891 Pyruvate carboxyltransferase
10090 IPR011764 Biotin carboxylation domain
10073 IPR000086 NUDIX hydrolase domain
10037 IPR000489 Pterin-binding domain
10017 IPR001387 Cro/C1-type helix-turn-helix domain
9932 IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
9915 IPR039562 Membrane fusion protein, biotin-lipoyl like domain
9907 IPR046867 Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain
9891 IPR026444 Secretion system C-terminal sorting domain
9888 IPR006091 Acyl-CoA oxidase/dehydrogenase, middle domain
9877 IPR006218 DAHP synthetase I/KDSA
9871 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF
9824 IPR024041 Ammonium transporter AmtB-like domain
9823 IPR001347 SIS domain
9782 IPR004045 Glutathione S-transferase, N-terminal
9703 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain
9667 IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
9615 IPR001478 PDZ domain
9587 IPR013108 Amidohydrolase 3
9569 IPR013766 Thioredoxin domain
9560 IPR009081 Phosphopantetheine binding ACP domain
9547 IPR001182 Probable peptidoglycan glycosyltransferase FtsW/RodA
9469 IPR017941 Rieske [2Fe-2S] iron-sulphur domain
9447 IPR025944 Sigma-54 interaction domain, conserved site
9364 IPR001451 Hexapeptide repeat
9357 IPR000601 PKD domain
9310 IPR022488 Polyphosphate kinase-2-related
9299 IPR002305 Aminoacyl-tRNA synthetase, class Ic
9292 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding
9278 IPR039429 Serine hydroxymethyltransferase-like domain
9273 IPR006171 TOPRIM domain
9203 IPR018164 Alanyl-tRNA synthetase, class IIc, N-terminal
9067 IPR002197 DNA binding HTH domain, Fis-type
8995 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain
8963 IPR002912 ACT domain
8941 IPR011453 Protein of unknown function DUF1559
8932 IPR015890 Chorismate-utilising enzyme, C-terminal
8884 IPR013221 Mur ligase, central
8839 IPR013149 Alcohol dehydrogenase-like, C-terminal
8685 IPR003692 Hydantoinase B/oxoprolinase
8666 IPR011761 ATP-grasp fold
8654 IPR001670 Alcohol dehydrogenase, iron-type/glycerol dehydrogenase GldA
8637 IPR006674 HD domain
8634 IPR006145 Pseudouridine synthase, RsuA/RluA-like
8490 IPR003667 NqrDE/RnfAE
8486 IPR011611 Carbohydrate kinase PfkB
8479 IPR014284 RNA polymerase sigma-70 like domain
8461 IPR014031 Beta-ketoacyl synthase, C-terminal
8452 IPR008915 Peptidase M50
8444 IPR021135 Phosphoenolpyruvate carboxylase
8422 IPR015413 Methionyl/Leucyl tRNA synthetase
8369 IPR019546 Twin-arginine translocation pathway, signal sequence, bacterial/archaeal
8360 IPR002110 Ankyrin repeat
8356 IPR004436 Isocitrate dehydrogenase NADP-dependent, monomeric
8267 IPR011708 Bacterial DNA polymerase III, alpha subunit, NTPase domain
8265 IPR004131 Pyrophosphate-energised proton pump
8194 IPR007120 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain
8180 IPR002933 Peptidase M20
8165 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
8131 IPR002898 MotA/TolQ/ExbB proton channel
8123 IPR005474 Transketolase, N-terminal
8083 IPR020617 Thiolase, C-terminal
8067 IPR001114 Adenylosuccinate synthetase
8063 IPR002692 Penicillin/GL-7-ACA/AHL/aculeacin-A acylase
8027 IPR014017 UvrD-like DNA helicase, C-terminal
8025 IPR035587 DUS-like, FMN-binding domain
8001 IPR018511 Hemolysin-type calcium-binding conserved site
7961 IPR006047 Glycosyl hydrolase, family 13, catalytic domain
7940 IPR010281 Protein of unknown function DUF885
7929 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
7913 IPR015793 Pyruvate kinase, barrel
7905 IPR001106 Aromatic amino acid lyase
7870 IPR000253 Forkhead-associated (FHA) domain
7842 IPR001107 Band 7 domain
7831 IPR019775 WD40 repeat, conserved site
7828 IPR003362 Bacterial sugar transferase
7809 IPR011110 Two component regulator propeller
7769 IPR007484 Peptidase M28
7751 IPR041698 Methyltransferase domain 25
7731 IPR001915 Peptidase M48
7725 IPR016047 Peptidase M23
7725 IPR011115 SecA DEAD-like, N-terminal
7699 IPR011650 Peptidase M20, dimerisation domain
7695 IPR004338 Ion-translocating oxidoreductase NqrB/RnfD
7689 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal
7636 IPR004846 Type II/III secretion system
7624 IPR012938 Glucose/Sorbosone dehydrogenase
7599 IPR001093 IMP dehydrogenase/GMP reductase
7569 IPR025667 SprB repeat
7465 IPR010496 3-keto-disaccharide hydrolase
7444 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
7436 IPR002035 von Willebrand factor, type A
7424 IPR006094 FAD linked oxidase, N-terminal
7412 IPR001567 Peptidase M3A/M3B catalytic domain
7381 IPR025943 Sigma-54 interaction domain, ATP-binding site 2
7366 IPR000522 ABC transporter, permease protein, BtuC-like
7341 IPR040131 MnmG, N-terminal domain
7321 IPR003367 Thrombospondin, type 3-like repeat
7320 IPR002220 DapA-like
7291 IPR003148 Regulator of K+ conductance, N-terminal
7290 IPR002123 Phospholipid/glycerol acyltransferase
7274 IPR000559 Formate-tetrahydrofolate ligase, FTHFS
7236 IPR003726 Homocysteine-binding domain
7229 IPR013497 DNA topoisomerase, type IA, central
7229 IPR001128 Cytochrome P450
7218 IPR006195 Aminoacyl-tRNA synthetase, class II
7203 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain
7157 IPR001932 PPM-type phosphatase-like domain
7145 IPR001672 Phosphoglucose isomerase (PGI)
7140 IPR002192 Pyruvate phosphate dikinase, AMP/ATP-binding
7091 IPR005151 Tail specific protease
7075 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
7060 IPR000640 Elongation factor EFG, domain V-like
7015 IPR006062 Histidine biosynthesis protein
6973 IPR018392 LysM domain
6927 IPR000819 Peptidase M17, leucyl aminopeptidase, C-terminal
6916 IPR001098 DNA-directed DNA polymerase, family A, palm domain
6912 IPR018461 Na+/H+ antiporter, NhaC-like, C-terminal
6864 IPR000760 Inositol monophosphatase-like
6842 IPR004113 FAD-linked oxidase, C-terminal
6803 IPR011234 Fumarylacetoacetase-like, C-terminal
6802 IPR011447 Protein of unknown function DUF1552
6773 IPR000845 Nucleoside phosphorylase domain
6762 IPR001272 Phosphoenolpyruvate carboxykinase, ATP-utilising
6733 IPR006657 Molybdopterin dinucleotide-binding domain
6693 IPR000092 Polyprenyl synthetase
6679 IPR013767 PAS fold
6676 IPR011429 Cytochrome C, Planctomycete-type
6672 IPR019307 RNA-binding protein AU-1/Ribonuclease E/G
6666 IPR025662 Sigma-54 interaction domain, ATP-binding site 1
6662 IPR002616 tRNA-guanine(15) transglycosylase-like
6661 IPR001576 Phosphoglycerate kinase
6647 IPR033248 Transketolase, C-terminal domain
6646 IPR007698 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain
6646 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
6620 IPR007630 RNA polymerase sigma-70 region 4
6612 IPR020581 Glycine cleavage system P protein
6584 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal
6567 IPR002125 Cytidine and deoxycytidylate deaminase domain
6560 IPR006035 Ureohydrolase
6557 IPR034300 NADP transhydrogenase beta-like domain
6533 IPR006175 YjgF/YER057c/UK114 family
6523 IPR044068 Core-binding (CB) domain
6517 IPR001764 Glycoside hydrolase, family 3, N-terminal
6465 IPR006158 Cobalamin (vitamin B12)-binding domain
6446 IPR001712 Type III secretion system FHIPEP
6444 IPR003346 Transposase, IS116/IS110/IS902
6399 IPR003869 Polysaccharide biosynthesis protein, CapD-like domain
6393 IPR008258 Transglycosylase SLT domain 1
6391 IPR007863 Peptidase M16, C-terminal
6381 IPR000905 Gcp-like domain
6347 IPR010918 PurM-like, C-terminal domain
6347 IPR002575 Aminoglycoside phosphotransferase
6343 IPR029065 Enolase C-terminal domain-like
6310 IPR024932 Flavin transferase ApbE
6300 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
6297 IPR000023 Phosphofructokinase domain
6293 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain
6284 IPR011517 RNA polymerase sigma-70 ECF-like
6280 IPR001537 tRNA/rRNA methyltransferase, SpoU type
6269 IPR033764 SD-repeat containing protein, B domain
6262 IPR020829 Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain
6258 IPR000524 Transcription regulator HTH, GntR
6248 IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain
6241 IPR006037 Regulator of K+ conductance, C-terminal
6221 IPR005139 Peptide chain release factor
6214 IPR000537 UbiA prenyltransferase family
6210 IPR020810 Enolase, C-terminal TIM barrel domain
6209 IPR012000 Thiamine pyrophosphate enzyme, central domain
6166 IPR001242 Condensation domain
6154 IPR012131 Histidinol dehydrogenase
6142 IPR002376 Formyl transferase, N-terminal
6142 IPR001264 Glycosyl transferase, family 51
6124 IPR018181 Heat shock protein 70, conserved site
6075 IPR000551 MerR-type HTH domain
6074 IPR001518 Argininosuccinate synthase
6070 IPR000297 Peptidyl-prolyl cis-trans isomerase, PpiC-type
6061 IPR025669 AAA domain
6046 IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I
6038 IPR013424 PEP-CTERM protein-sorting domain
6025 IPR001123 Amino acid exporter protein, LeuE-type
6022 IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase
6019 IPR002052 DNA methylase, N-6 adenine-specific, conserved site
6005 IPR004147 ABC1 atypical kinase-like domain
6001 IPR023302 Peptidase S9A, N-terminal domain
6000 IPR041492 Haloacid dehalogenase-like hydrolase
5997 IPR002129 Pyridoxal phosphate-dependent decarboxylase
5991 IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
5990 IPR010426 Trimethylamine methyltransferase
5964 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal
5930 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat
5930 IPR000453 Chorismate synthase
5927 IPR013078 Histidine phosphatase superfamily, clade-1
5887 IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal
5880 IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
5874 IPR002645 STAS domain
5863 IPR002830 UbiD decarboxylyase family
5859 IPR022764 Peptidase S54, rhomboid domain
5848 IPR002423 Chaperonin Cpn60/GroEL/TCP-1 family
5831 IPR013765 DNA recombination and repair protein RecA
5829 IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H
5819 IPR008269 Peptidase S16, Lon proteolytic domain
5813 IPR002695 Bifunctional purine biosynthesis protein PurH-like
5792 IPR033756 Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35
5792 IPR002208 SecY/SEC61-alpha family
5790 IPR000257 Uroporphyrinogen decarboxylase (URO-D)
5746 IPR016166 FAD-binding domain, PCMH-type
5732 IPR006530 YD repeat
5730 IPR031157 Tr-type G domain, conserved site
5713 IPR040982 DNA polymerase III alpha subunit finger domain
5688 IPR004697 p-Aminobenzoyl-glutamate transport protein AbgT
5678 IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
5645 IPR022813 Protein-export membrane protein SecD/SecF, archaeal and bacterial
5644 IPR030395 Glycerophosphodiester phosphodiesterase domain
5641 IPR006194 Glycine-tRNA synthetase, heterodimeric
5638 IPR002880 Pyruvate flavodoxin/ferredoxin oxidoreductase, pyrimidine binding domain
5636 IPR008257 Peptidase M19
5592 IPR032678 tRNA synthetases class I, catalytic domain
5592 IPR004107 Integrase, SAM-like, N-terminal
5570 IPR000825 SUF system FeS cluster assembly, SufBD
5554 IPR001465 Malate synthase
5549 IPR001440 Tetratricopeptide repeat 1
5546 IPR003699 S-adenosylmethionine:tRNA ribosyltransferase-isomerase, QueA
5517 IPR001544 Aminotransferase class IV
5463 IPR005517 Translation elongation factor EFG/EF2, domain IV
5453 IPR007694 DNA helicase, DnaB-like, C-terminal
5441 IPR000175 Sodium:neurotransmitter symporter
5424 IPR013655 PAS fold-3
5418 IPR039648 Pyridine nucleotide-disulphide oxidoreductase, N-terminal
5395 IPR004143 Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain
5387 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal
5379 IPR013839 NAD-dependent DNA ligase, adenylation
5376 IPR029510 Aldehyde dehydrogenase, glutamic acid active site
5374 IPR000943 RNA polymerase sigma-70
5353 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal
5342 IPR029479 Nitroreductase
5338 IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
5332 IPR006089 Acyl-CoA dehydrogenase, conserved site
5330 IPR002142 Peptidase S49
5328 IPR001130 3'-5' ssDNA/RNA exonuclease TatD-like
5311 IPR002938 FAD-binding domain
5308 IPR013976 Metal-dependent hydrolase HDOD
5299 IPR013105 Tetratricopeptide repeat 2
5299 IPR000600 ROK family
5293 IPR004184 Pyruvate formate lyase domain
5290 IPR030802 ABC transporter permease MalE
5290 IPR006683 Thioesterase domain
5264 IPR016188 PurM-like, N-terminal domain
5255 IPR005481 Biotin carboxylase-like, N-terminal domain
5253 IPR005017 Outer membrane protein transport protein (OMPP1/FadL/TodX)
5251 IPR004101 Mur ligase, C-terminal
5239 IPR003331 UDP-N-acetylglucosamine 2-epimerase domain
5227 IPR002569 Peptide methionine sulphoxide reductase MsrA domain
5227 IPR000835 MarR-type HTH domain
5224 IPR017456 CTP synthase, N-terminal
5215 IPR019861 Type IX secretion system membrane protein, PorP/SprF family
5204 IPR003400 Biopolymer transport protein ExbD/TolR
5203 IPR001453 MoaB/Mog domain
5197 IPR046335 Transcriptional regulator LacI/GalR-like, sensor domain
5197 IPR004291 Transposase IS66, central domain
5177 IPR003781 CoA-binding
5162 IPR004670 Na+/H+ antiporter NhaA
5159 IPR002641 Patatin-like phospholipase domain
5155 IPR019489 Clp ATPase, C-terminal


GO-slim

GO slim is a cut-down version of the GO ontologies that contain only a subset of terms from the GO resource. metaGOflow provides both a full GO annotation which is not displayed here as it is rather long and a slim version like the one shown here for the sediment case. On the first column there is the GO id, on the second its description, on the third its the GO ontology it belogs to (biological process, cellular component, molecular function) and on the fourth one we have the number of hits of the annotation on the reads.

GO:0008150 biological process biological_process 36605
GO:0071973 bacterial-type flagellar cell motility biological_process 8297
GO:0071840 cellular component organization or biogenesis biological_process 51015
GO:0071103 DNA conformation change biological_process 36743
GO:0045454 cell redox homeostasis biological_process 7193
GO:0065003 macromolecular complex assembly biological_process 3520
GO:0016226 iron-sulfur cluster assembly biological_process 10827
GO:0017004 cytochrome complex assembly biological_process 9958
GO:0008152 metabolic process biological_process 102385
GO:0008218 bioluminescence biological_process 615
GO:0009058 biosynthetic process biological_process 552434
GO:0017000 antibiotic biosynthetic process biological_process 8063
GO:0009403 toxin biosynthetic process biological_process 1454
GO:0006259 DNA metabolic process biological_process 242519
GO:0016070 RNA metabolic process biological_process 193244
GO:0009317 acetyl-CoA carboxylase complex cellular_component 2171
GO:0009349 riboflavin synthase complex cellular_component 2373
GO:0009346 citrate lyase complex cellular_component 225
GO:0043190 ATP-binding cassette (ABC) transporter complex cellular_component 18517
GO:0000015 phosphopyruvate hydratase complex cellular_component 0
GO:0009341 beta-galactosidase complex cellular_component 1827
GO:0019008 molybdopterin synthase complex cellular_component 1363
GO:1990204 oxidoreductase complex cellular_component 2011
GO:0033202 DNA helicase complex cellular_component 739
GO:0042575 DNA polymerase complex cellular_component 6469
GO:0098796 membrane protein complex cellular_component 752
GO:0016469 proton-transporting two-sector ATPase complex cellular_component 10876
GO:0005839 proteasome core complex cellular_component 1802
GO:0005874 microtubule cellular_component 119
GO:0048500 signal recognition particle cellular_component 2055
GO:0009288 bacterial type flagellum cellular_component 11096
GO:0005840 ribosome cellular_component 84272
GO:0005694 chromosome cellular_component 2085
GO:0005727 extrachromosomal circular DNA cellular_component 0
GO:0005634 nucleus cellular_component 89
GO:0009579 thylakoid cellular_component 44
GO:0019012 virion cellular_component 5
GO:0003674 molecular function molecular_function 68079
GO:0016209 antioxidant activity molecular_function 18108
GO:0004601 peroxidase activity molecular_function 8306
GO:0003824 catalytic activity molecular_function 227423
GO:0016787 hydrolase activity molecular_function 393109
GO:0008233 peptidase activity molecular_function 175119
GO:0016791 phosphatase activity molecular_function 11856
GO:0017111 nucleoside-triphosphatase activity molecular_function 143755
GO:0009055 electron carrier activity molecular_function 60810
GO:0016853 isomerase activity molecular_function 150834
GO:0016874 ligase activity molecular_function 249431
GO:0016829 lyase activity molecular_function 170518
GO:0016491 oxidoreductase activity molecular_function 658464
GO:0000150 recombinase activity molecular_function 6392
GO:0004803 transposase activiy molecular_function 29571


KEGG terms (KOs)

Similar to the IPS case, on the first column we get the number of hits an id had among the reads, on the second the KO and on the third its description.

13772 K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
13701 K07497 putative transposase
10371 K03310 alanine or glycine:cation symporter, AGCS family
9015 K03406 methyl-accepting chemotaxis protein
8548 K07486 transposase
8349 K01915 glutamine synthetase [EC:6.3.1.2]
7961 K00428 cytochrome c peroxidase [EC:1.11.1.5]
7596 K00789 S-adenosylmethionine synthetase [EC:2.5.1.6]
7568 K00134 glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]
7544 K00600 glycine hydroxymethyltransferase [EC:2.1.2.1]
7523 K00873 pyruvate kinase [EC:2.7.1.40]
6706 K03466 DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family
6606 K01712 urocanate hydratase [EC:4.2.1.49]
6288 K01689 enolase [EC:4.2.1.11]
6104 K01937 CTP synthase [EC:6.3.4.2]
5999 K03734 FAD:protein FMN transferase [EC:2.7.1.180]
5807 K02600 transcription termination/antitermination protein NusA
5526 K01251 adenosylhomocysteinase [EC:3.3.1.1]
5469 K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
5012 K03559 biopolymer transport protein ExbD
4746 K03092 RNA polymerase sigma-54 factor
4720 K01610 phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49]
4682 K03313 Na+:H+ antiporter, NhaA family
4447 K06888 uncharacterized protein
4373 K08303 putative protease [EC:3.4.-.-]
4345 K00948 ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
4297 K00688 glycogen phosphorylase [EC:2.4.1.1]
4285 K15371 glutamate dehydrogenase [EC:1.4.1.2]
4282 K07491 putative transposase
4178 K01698 porphobilinogen synthase [EC:4.2.1.24]
4114 K03701 excinuclease ABC subunit A
4109 K03924 MoxR-like ATPase [EC:3.6.3.-]
4100 K04077 chaperonin GroEL
4033 K03118 sec-independent protein translocase protein TatC
4028 K07304 peptide-methionine (S)-S-oxide reductase [EC:1.8.4.11]
4005 K01595 phosphoenolpyruvate carboxylase [EC:4.1.1.31]
3983 K02066 phospholipid/cholesterol/gamma-HCH transport system permease protein
3964 K01939 adenylosuccinate synthase [EC:6.3.4.4]
3924 K03040 DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
3882 K04079 molecular chaperone HtpG
3858 K02338 DNA polymerase III subunit beta [EC:2.7.7.7]
3833 K07462 single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
3769 K03553 recombination protein RecA
3732 K01803 triosephosphate isomerase (TIM) [EC:5.3.1.1]
3693 K03088 RNA polymerase sigma-70 factor, ECF subfamily
3648 K04096 DNA processing protein
3633 K03527 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4]
3625 K03147 phosphomethylpyrimidine synthase [EC:4.1.99.17]
3576 K01673 carbonic anhydrase [EC:4.2.1.1]
3544 K01918 pantoate--beta-alanine ligase [EC:6.3.2.1]
3538 K06941 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192]
3537 K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]
3484 K01358 ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
3482 K03111 single-strand DNA-binding protein
3452 K03561 biopolymer transport protein ExbB
3392 K01448 N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]
3388 K02015 iron complex transport system permease protein
3332 K02838 ribosome recycling factor
3272 K01887 arginyl-tRNA synthetase [EC:6.1.1.19]
3228 K01246 DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
3224 K06153 undecaprenyl-diphosphatase [EC:3.6.1.27]
3205 K06076 long-chain fatty acid transport protein
3179 K00606 3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11]
3135 K03601 exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
3062 K01462 peptide deformylase [EC:3.5.1.88]
3054 K04078 chaperonin GroES
3025 K01626 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]
2988 K06911 uncharacterized protein
2982 K22468 polyphosphate kinase [EC:2.7.4.1]
2945 K04564 superoxide dismutase, Fe-Mn family [EC:1.15.1.1]
2935 K01875 seryl-tRNA synthetase [EC:6.1.1.11]
2919 K03497 ParB family transcriptional regulator, chromosome partitioning protein
2889 K03664 SsrA-binding protein
2884 K00793 riboflavin synthase [EC:2.5.1.9]
2883 K03101 signal peptidase II [EC:3.4.23.36]
2880 K07052 uncharacterized protein
2828 K03687 molecular chaperone GrpE
2820 K03744 LemA protein
2774 K03522 electron transfer flavoprotein alpha subunit
2736 K03630 DNA repair protein RadC
2726 K00507 stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]
2717 K03521 electron transfer flavoprotein beta subunit
2701 K02437 glycine cleavage system H protein
2656 K03312 glutamate:Na+ symporter, ESS family
2647 K06958 RNase adapter protein RapZ
2642 K01619 deoxyribose-phosphate aldolase [EC:4.1.2.4]
2635 K00275 pyridoxamine 5'-phosphate oxidase [EC:1.4.3.5]
2627 K00858 NAD+ kinase [EC:2.7.1.23]
2562 K00573 protein-L-isoaspartate(D-aspartate) O-methyltransferase [EC:2.1.1.77]
2556 K01940 argininosuccinate synthase [EC:6.3.4.5]
2539 K00765 ATP phosphoribosyltransferase [EC:2.4.2.17]
2535 K01159 crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4]
2533 K09930 uncharacterized protein
2481 K03551 holliday junction DNA helicase RuvB [EC:3.6.4.12]
2466 K00163 pyruvate dehydrogenase E1 component [EC:1.2.4.1]
2459 K02078 acyl carrier protein
2398 K07493 putative transposase
2386 K00937 polyphosphate kinase [EC:2.7.4.1]
2377 K07082 UPF0755 protein
2370 K01790 dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]
2364 K02520 translation initiation factor IF-3
2310 K01409 N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
2308 K02897 large subunit ribosomal protein L25
2306 K02935 large subunit ribosomal protein L7/L12
2292 K02879 large subunit ribosomal protein L17
2283 K00228 coproporphyrinogen III oxidase [EC:1.3.3.3]
2234 K07058 membrane protein
2233 K06204 DnaK suppressor protein
2204 K03782 catalase-peroxidase [EC:1.11.1.21]
2198 K01972 DNA ligase (NAD+) [EC:6.5.1.2]
2191 K00798 cob(I)alamin adenosyltransferase [EC:2.5.1.17]
2181 K07568 S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]
2168 K00981 phosphatidate cytidylyltransferase [EC:2.7.7.41]
2156 K01056 peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]
2135 K07560 D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
2134 K00865 glycerate 2-kinase [EC:2.7.1.165]
2120 K03808 paraquat-inducible protein A
2101 K00286 pyrroline-5-carboxylate reductase [EC:1.5.1.2]
2092 K00794 6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78]
2079 K04066 primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:3.6.4.-]
2075 K07068 uncharacterized protein
2074 K12942 aminobenzoyl-glutamate transport protein
2070 K18979 epoxyqueuosine reductase [EC:1.17.99.6]
2054 K03702 excinuclease ABC subunit B
2044 K02888 large subunit ribosomal protein L21
2008 K07089 uncharacterized protein
2007 K07738 transcriptional repressor NrdR
2000 K01495 GTP cyclohydrolase IA [EC:3.5.4.16]
1996 K03070 preprotein translocase subunit SecA [EC:7.4.2.8]
1992 K06187 recombination protein RecR
1982 K06997 PLP dependent protein
1975 K01695 tryptophan synthase alpha chain [EC:4.2.1.20]
1972 K01613 phosphatidylserine decarboxylase [EC:4.1.1.65]
1966 K09710 ribosome-associated protein
1942 K01809 mannose-6-phosphate isomerase [EC:5.3.1.8]
1941 K00426 cytochrome bd ubiquinol oxidase subunit II [EC:7.1.1.7]
1931 K03781 catalase [EC:1.11.1.6]
1928 K09747 uncharacterized protein
1924 K02410 flagellar motor switch protein FliG
1921 K02884 large subunit ribosomal protein L19
1919 K07402 xanthine dehydrogenase accessory factor
1919 K03621 phosphate acyltransferase [EC:2.3.1.274]
1897 K03526 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1 1.17.7.3]
1891 K03635 molybdopterin synthase catalytic subunit [EC:2.8.1.12]
1890 K00859 dephospho-CoA kinase [EC:2.7.1.24]
1864 K01737 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]
1862 K03569 rod shape-determining protein MreB and related proteins
1853 K03801 lipoyl(octanoyl) transferase [EC:2.3.1.181]
1846 K03584 DNA repair protein RecO (recombination protein O)
1843 K05896 segregation and condensation protein A
1835 K03563 carbon storage regulator
1823 K09861 uncharacterized protein
1822 K07735 putative transcriptional regulator
1822 K06024 segregation and condensation protein B
1819 K09748 ribosome maturation factor RimP
1817 K21929 uracil-DNA glycosylase [EC:3.2.2.27]
1810 K01724 4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96]
1809 K09903 uridylate kinase [EC:2.7.4.22]
1806 K01273 membrane dipeptidase [EC:3.4.13.19]
1800 K01778 diaminopimelate epimerase [EC:5.1.1.7]
1795 K02492 glutamyl-tRNA reductase [EC:1.2.1.70]
1794 K07126 uncharacterized protein
1769 K21470 L,D-transpeptidase YcbB
1767 K00549 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [EC:2.1.1.14]
1746 K11749 regulator of sigma E protease [EC:3.4.24.-]
1745 K01077 alkaline phosphatase [EC:3.1.3.1]
1733 K02834 ribosome-binding factor A
1721 K03832 periplasmic protein TonB
1718 K02887 large subunit ribosomal protein L20
1709 K07393 glutathionyl-hydroquinone reductase [EC:1.8.5.7]
1690 K02871 large subunit ribosomal protein L13
1687 K06199 fluoride exporter
1687 K01951 GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
1672 K02878 large subunit ribosomal protein L16
1668 K07240 chromate transporter
1658 K03282 large conductance mechanosensitive channel
1655 K03545 trigger factor
1655 K02876 large subunit ribosomal protein L15
1648 K00635 diacylglycerol O-acyltransferase / wax synthase [EC:2.3.1.20 2.3.1.75]
1643 K02909 large subunit ribosomal protein L31
1637 K07447 putative holliday junction resolvase [EC:3.1.-.-]
1632 K00099 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267]
1624 K01752 L-serine dehydratase [EC:4.3.1.17]
1621 K06415 stage V sporulation protein R
1602 K02990 small subunit ribosomal protein S6
1597 K02959 small subunit ribosomal protein S16
1597 K01653 acetolactate synthase I/III small subunit [EC:2.2.1.6]
1594 K09125 uncharacterized protein
1588 K00951 GTP pyrophosphokinase [EC:2.7.6.5]
1566 K02867 large subunit ribosomal protein L11
1560 K09919 uncharacterized protein
1554 K01638 malate synthase [EC:2.3.3.9]
1543 K00954 pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]
1526 K01095 phosphatidylglycerophosphatase A [EC:3.1.3.27]
1521 K02004 putative ABC transport system permease protein
1518 K06925 tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
1516 K03570 rod shape-determining protein MreC
1515 K04754 phospholipid-binding lipoprotein MlaA
1512 K00432 glutathione peroxidase [EC:1.11.1.9]
1505 K07112 uncharacterized protein
1505 K07054 uncharacterized protein
1500 K07093 uncharacterized protein
1490 K07090 uncharacterized protein
1476 K00560 thymidylate synthase [EC:2.1.1.45]
1466 K03210 preprotein translocase subunit YajC
1449 K14266 tryptophan 7-halogenase [EC:1.14.19.9]
1444 K02860 16S rRNA processing protein RimM
1442 K03558 membrane protein required for colicin V production
1442 K01507 inorganic pyrophosphatase [EC:3.6.1.1]
1431 K03325 arsenite transporter
1428 K07484 transposase
1424 K01607 4-carboxymuconolactone decarboxylase [EC:4.1.1.44]
1418 K02899 large subunit ribosomal protein L27
1413 K02197 cytochrome c-type biogenesis protein CcmE
1409 K07152 protein SCO1/2
1407 K06949 ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]
1404 K09767 cyclic-di-GMP-binding protein
1403 K07460 putative endonuclease
1399 K07234 uncharacterized protein involved in response to NO
1399 K02238 competence protein ComEC
1387 K02954 small subunit ribosomal protein S14
1386 K02950 small subunit ribosomal protein S12
1382 K03186 flavin prenyltransferase [EC:2.5.1.129]
1374 K03637 cyclic pyranopterin monophosphate synthase [EC:4.6.1.17]
1371 K02968 small subunit ribosomal protein S20
1371 K00945 CMP/dCMP kinase [EC:2.7.4.25]
1370 K00287 dihydrofolate reductase [EC:1.5.1.3]
1369 K09927 uncharacterized protein
1350 K00540 F420H(2)-dependent quinone reductase [EC:1.1.98.-]


Pfam

Like in the IPS and the KEGG cases.

115018 PF00005 ABC transporter
73852 PF00884 Sulfatase
71296 PF00873 AcrB/AcrD/AcrF family
61482 PF00072 Response regulator receiver domain
59116 PF00171 Aldehyde dehydrogenase family
54482 PF00106 short chain dehydrogenase
53966 PF00501 AMP-binding enzyme
43792 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
40905 PF00990 Diguanylate cyclase, GGDEF domain
39522 PF07394 Protein of unknown function (DUF1501)
37109 PF00069 Protein kinase domain
34621 PF00158 Sigma-54 interaction domain
31267 PF00155 Aminotransferase class I and II
28968 PF13561 Enoyl-(Acyl carrier protein) reductase
27324 PF00563 EAL domain
26516 PF13517 FG-GAP-like repeat
26207 PF00202 Aminotransferase class-III
25877 PF00528 Binding-protein-dependent transport system inner membrane component
25372 PF00437 Type II/IV secretion system protein
24069 PF00378 Enoyl-CoA hydratase/isomerase
24012 PF00512 His Kinase A (phospho-acceptor) domain
23974 PF00009 Elongation factor Tu GTP binding domain
23935 PF00535 Glycosyl transferase family 2
23324 PF00133 tRNA synthetases class I (I, L, M and V)
22485 PF00266 Aminotransferase class-V
22307 PF01370 NAD dependent epimerase/dehydratase family
21698 PF04542 Sigma-70 region 2
21628 PF00441 Acyl-CoA dehydrogenase, C-terminal domain
21452 PF00012 Hsp70 protein
21018 PF03466 LysR substrate binding domain
20979 PF01053 Cys/Met metabolism PLP-dependent enzyme
20576 PF00571 CBS domain
20441 PF00126 Bacterial regulatory helix-turn-helix protein, lysR family
20188 PF07676 WD40-like Beta Propeller Repeat
19818 PF06808 Tripartite ATP-independent periplasmic transporter, DctM component
19175 PF02515 CoA-transferase family III
18783 PF00361 Proton-conducting membrane transporter
18745 PF07583 Protein of unknown function (DUF1549)
18661 PF07992 Pyridine nucleotide-disulphide oxidoreductase
18266 PF07587 Protein of unknown function (DUF1553)
18130 PF17803 Bacterial cadherin-like domain
18027 PF00271 Helicase conserved C-terminal domain
18015 PF12228 Protein of unknown function (DUF3604)
18007 PF00270 DEAD/DEAH box helicase
17618 PF00384 Molybdopterin oxidoreductase
17375 PF00890 FAD binding domain
17161 PF00296 Luciferase-like monooxygenase
16908 PF01041 DegT/DnrJ/EryC1/StrS aminotransferase family
16388 PF00534 Glycosyl transferases group 1
16353 PF00291 Pyridoxal-phosphate dependent enzyme
16226 PF00115 Cytochrome C and Quinol oxidase polypeptide I
16009 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain
15833 PF17963 Bacterial Ig domain
15708 PF00330 Aconitase family (aconitate hydratase)
15665 PF02771 Acyl-CoA dehydrogenase, N-terminal domain
15551 PF00108 Thiolase, N-terminal domain
15375 PF00144 Beta-lactamase
15270 PF01039 Carboxyl transferase domain
15259 PF17892 Cadherin-like domain
15074 PF00326 Prolyl oligopeptidase family
15062 PF00117 Glutamine amidotransferase class-I
14668 PF00486 Transcriptional regulatory protein, C terminal
14577 PF01019 Gamma-glutamyltranspeptidase
14563 PF00353 RTX calcium-binding nonapeptide repeat (4 copies)
14403 PF00109 Beta-ketoacyl synthase, N-terminal domain
14266 PF16363 GDP-mannose 4,6 dehydratase
14190 PF00474 Sodium:solute symporter family
14121 PF13424 Tetratricopeptide repeat
14106 PF01266 FAD dependent oxidoreductase
13834 PF00589 Phage integrase family
13797 PF02321 Outer membrane efflux protein
13646 PF00004 ATPase family associated with various cellular activities (AAA)
13597 PF00152 tRNA synthetases class II (D, K and N)
13559 PF00483 Nucleotidyl transferase
13399 PF01345 Domain of unknown function DUF11
13394 PF08241 Methyltransferase domain
13325 PF07715 TonB-dependent Receptor Plug Domain
13324 PF00440 Bacterial regulatory proteins, tetR family
13263 PF07963 Prokaryotic N-terminal methylation motif
13238 PF05088 Bacterial NAD-glutamate dehydrogenase
13156 PF00753 Metallo-beta-lactamase superfamily
13132 PF01926 50S ribosome-binding GTPase
13063 PF01642 Methylmalonyl-CoA mutase
13043 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
13018 PF01979 Amidohydrolase family
12954 PF00248 Aldo/keto reductase family
12951 PF00924 Mechanosensitive ion channel
12873 PF08281 Sigma-70, region 4
12863 PF00082 Subtilase family
12783 PF03781 Sulfatase-modifying factor enzyme 1
12764 PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle
12624 PF00006 ATP synthase alpha/beta family, nucleotide-binding domain
12572 PF02779 Transketolase, pyrimidine binding domain
12571 PF00561 alpha/beta hydrolase fold
12517 PF01645 Conserved region in glutamate synthase
12498 PF00593 TonB dependent receptor
12495 PF13193 AMP-binding enzyme C-terminal domain
12491 PF02687 FtsX-like permease family
12476 PF00905 Penicillin binding protein transpeptidase domain
12404 PF01571 Aminomethyltransferase folate-binding domain
12225 PF00375 Sodium:dicarboxylate symporter family
12215 PF01408 Oxidoreductase family, NAD-binding Rossmann fold
12165 PF01235 Sodium:alanine symporter family
12037 PF00575 S1 RNA binding domain
12036 PF00583 Acetyltransferase (GNAT) family
11936 PF00206 Lyase
11846 PF01425 Amidase
11778 PF01554 MatE
11764 PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
11746 PF00400 WD domain, G-beta repeat
11689 PF00749 tRNA synthetases class I (E and Q), catalytic domain
11630 PF00275 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
11568 PF00580 UvrD/REP helicase N-terminal domain
11548 PF07690 Major Facilitator Superfamily
11524 PF00015 Methyl-accepting chemotaxis protein (MCP) signalling domain
11519 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
11212 PF00733 Asparagine synthase
11210 PF00672 HAMP domain
11168 PF02867 Ribonucleotide reductase, barrel domain
11164 PF00180 Isocitrate/isopropylmalate dehydrogenase
11145 PF02028 BCCT, betaine/carnitine/choline family transporter
11139 PF00920 Dehydratase family
10977 PF00582 Universal stress protein family
10924 PF00557 Metallopeptidase family M24
10702 PF00285 Citrate synthase, C-terminal domain
10675 PF07724 AAA domain (Cdc48 subfamily)
10662 PF14559 Tetratricopeptide repeat
10554 PF00696 Amino acid kinase family
10506 PF00521 DNA gyrase/topoisomerase IV, subunit A
10412 PF02896 PEP-utilising enzyme, PEP-binding domain
10400 PF08240 Alcohol dehydrogenase GroES-like domain
10395 PF07726 ATPase family associated with various cellular activities (AAA)
10340 PF00120 Glutamine synthetase, catalytic domain
10330 PF00676 Dehydrogenase E1 component
10313 PF02738 Molybdopterin cofactor-binding domain
10295 PF00999 Sodium/hydrogen exchanger family
10293 PF00482 Type II secretion system (T2SS), protein F
10281 PF03480 Bacterial extracellular solute-binding protein, family 7
10194 PF00795 Carbon-nitrogen hydrolase
10150 PF00578 AhpC/TSA family
10142 PF00892 EamA-like transporter family
10111 PF00916 Sulfate permease family
10103 PF02653 Branched-chain amino acid transport system / permease component
10022 PF00196 Bacterial regulatory proteins, luxR family
10012 PF00293 NUDIX domain
9915 PF13533 Biotin-lipoyl like
9907 PF20256 Molybdopterin cofactor-binding domain
9888 PF02770 Acyl-CoA dehydrogenase, middle domain
9877 PF00793 DAHP synthetase I family
9871 PF00497 Bacterial extracellular solute-binding proteins, family 3
9834 PF00691 OmpA family
9824 PF00909 Ammonium Transporter Family
9703 PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
9587 PF07969 Amidohydrolase family
9547 PF01098 Cell cycle protein
9464 PF00211 Adenylate and Guanylate cyclase catalytic domain
9315 PF12833 Helix-turn-helix domain
9310 PF03976 Polyphosphate kinase 2 (PPK2)
9299 PF00579 tRNA synthetases class I (W and Y)
9292 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
9278 PF00464 Serine hydroxymethyltransferase
9203 PF01411 tRNA synthetases class II (A)
9200 PF00664 ABC transporter transmembrane region
9118 PF00037 4Fe-4S binding domain
9067 PF02954 Bacterial regulatory protein, Fis family
8955 PF00448 SRP54-type protein, GTPase domain
8941 PF07596 Protein of unknown function (DUF1559)
8932 PF00425 chorismate binding enzyme
8928 PF01839 FG-GAP repeat
8884 PF08245 Mur ligase middle domain
8859 PF00364 Biotin-requiring enzyme
8839 PF00107 Zinc-binding dehydrogenase
8685 PF02538 Hydantoinase B/oxoprolinase
8654 PF00465 Iron-containing alcohol dehydrogenase
8634 PF00849 RNA pseudouridylate synthase
8627 PF18911 PKD domain
8508 PF14312 FG-GAP repeat
8490 PF02508 Rnf-Nqr subunit, membrane protein
8486 PF00294 pfkB family carbohydrate kinase
8461 PF02801 Beta-ketoacyl synthase, C-terminal domain
8452 PF02163 Peptidase family M50
8444 PF00311 Phosphoenolpyruvate carboxylase
8422 PF09334 tRNA synthetases class I (M)
8356 PF03971 Monomeric isocitrate dehydrogenase
8330 PF13450 NAD(P)-binding Rossmann-like domain
8268 PF00550 Phosphopantetheine attachment site
8267 PF07733 Bacterial DNA polymerase III alpha NTPase domain
8265 PF03030 Inorganic H+ pyrophosphatase
8194 PF00562 RNA polymerase Rpb2, domain 6
8180 PF01546 Peptidase family M20/M25/M40
8164 PF00682 HMGL-like
8161 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
8131 PF01618 MotA/TolQ/ExbB proton channel family
8083 PF02803 Thiolase, C-terminal domain
8067 PF00709 Adenylosuccinate synthetase
8063 PF01804 Penicillin amidase
8025 PF01207 Dihydrouridine synthase (Dus)
7974 PF13361 UvrD-like helicase C-terminal domain
7961 PF00128 Alpha amylase, catalytic domain
7940 PF05960 Bacterial protein of unknown function (DUF885)
7929 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
7913 PF00224 Pyruvate kinase, barrel domain
7905 PF00221 Aromatic amino acid lyase
7842 PF01145 SPFH domain / Band 7 family
7828 PF02397 Bacterial sugar transferase
7809 PF07494 Two component regulator propeller
7769 PF04389 Peptidase family M28
7759 PF00122 E1-E2 ATPase
7758 PF00809 Pterin binding enzyme
7751 PF13649 Methyltransferase domain
7731 PF01435 Peptidase family M48
7725 PF07517 SecA DEAD-like domain
7725 PF01551 Peptidase family M23
7723 PF00581 Rhodanese-like domain
7713 PF00456 Transketolase, thiamine diphosphate binding domain
7699 PF07687 Peptidase dimerisation domain
7695 PF03116 NQR2, RnfD, RnfE family
7689 PF00724 NADH:flavin oxidoreductase / NADH oxidase family
7636 PF00263 Bacterial type II and III secretion system protein
7624 PF07995 Glucose / Sorbosone dehydrogenase
7599 PF00478 IMP dehydrogenase / GMP reductase domain
7569 PF13573 SprB repeat
7559 PF00355 Rieske [2Fe-2S] domain
7465 PF06439 3-keto-disaccharide hydrolase
7456 PF00132 Bacterial transferase hexapeptide (six repeats)
7444 PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase
7424 PF01565 FAD binding domain
7412 PF01432 Peptidase family M3
7380 PF04055 Radical SAM superfamily
7366 PF01032 FecCD transport family
7352 PF13432 Tetratricopeptide repeat
7341 PF01134 Glucose inhibited division protein A
7321 PF02412 Thrombospondin type 3 repeat
7320 PF00701 Dihydrodipicolinate synthetase family
7315 PF01966 HD domain
7290 PF01553 Acyltransferase
7283 PF00310 Glutamine amidotransferases class-II
7274 PF01268 Formate--tetrahydrofolate ligase
7243 PF02254 TrkA-N domain
7236 PF13437 HlyD family secretion protein
7233 PF02574 Homocysteine S-methyltransferase
7229 PF01131 DNA topoisomerase
7229 PF00067 Cytochrome P450
7190 PF13469 Sulfotransferase family
7172 PF00027 Cyclic nucleotide-binding domain
7140 PF01326 Pyruvate phosphate dikinase, AMP/ATP-binding domain
7091 PF03572 Peptidase family S41
7075 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
7060 PF00679 Elongation factor G C-terminus
7015 PF00977 Histidine biosynthesis protein
6981 PF00498 FHA domain
6927 PF00883 Cytosol aminopeptidase family, catalytic domain
6916 PF00476 DNA polymerase family A
6912 PF03553 Na+/H+ antiporter family
6864 PF00459 Inositol monophosphatase family
6842 PF02913 FAD linked oxidases, C-terminal domain
6803 PF01557 Fumarylacetoacetate (FAA) hydrolase family
6802 PF07586 Protein of unknown function (DUF1552)
6773 PF01048 Phosphorylase superfamily
6762 PF01293 Phosphoenolpyruvate carboxykinase
6733 PF01568 Molydopterin dinucleotide binding domain
6693 PF00348 Polyprenyl synthetase
6691 PF13365 Trypsin-like peptidase domain
6679 PF00989 PAS fold
6676 PF07635 Planctomycete cytochrome C
6672 PF10150 Ribonuclease E/G family
6662 PF01702 Queuine tRNA-ribosyltransferase
6661 PF00162 Phosphoglycerate kinase
6647 PF02780 Transketolase, C-terminal domain
6646 PF01262 Alanine dehydrogenase/PNT, C-terminal domain
6620 PF04545 Sigma-70, region 4
6613 PF01476 LysM domain
6612 PF13414 TPR repeat
6612 PF02347 Glycine cleavage system P-protein
6588 PF01380 SIS domain
6584 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
6557 PF02233 NAD(P) transhydrogenase beta subunit
6533 PF01042 Endoribonuclease L-PSP
6517 PF00933 Glycosyl hydrolase family 3 N terminal domain
6499 PF06723 MreB/Mbl protein
6458 PF01011 PQQ enzyme repeat
6446 PF00771 FHIPEP family
6444 PF02371 Transposase IS116/IS110/IS902 family
6428 PF18962 Secretion system C-terminal sorting domain
6416 PF00491 Arginase family
6399 PF02719 Polysaccharide biosynthesis protein
6393 PF01464 Transglycosylase SLT domain
6391 PF05193 Peptidase M16 inactive domain
6381 PF00814 tRNA N6-adenosine threonylcarbamoyltransferase
6347 PF02769 AIR synthase related protein, C-terminal domain
6347 PF01636 Phosphotransferase enzyme family
6343 PF13378 Enolase C-terminal domain-like
6310 PF02424 ApbE family
6300 PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
6297 PF00365 Phosphofructokinase
6293 PF13646 HEAT repeats
6284 PF07638 ECF sigma factor
6281 PF13692 Glycosyl transferases group 1
6280 PF00588 SpoU rRNA Methylase family
6269 PF17210 SdrD B-like domain
6262 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
6230 PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
6229 PF00034 Cytochrome c
6221 PF03462 PCRF domain
6214 PF01040 UbiA prenyltransferase family
6210 PF00113 Enolase, C-terminal TIM barrel domain
6209 PF00205 Thiamine pyrophosphate enzyme, central domain
6206 PF00392 Bacterial regulatory proteins, gntR family
6200 PF00342 Phosphoglucose isomerase
6166 PF00668 Condensation domain
6154 PF00815 Histidinol dehydrogenase
6150 PF07228 Stage II sporulation protein E (SpoIIE)
6142 PF00912 Transglycosylase
6142 PF00551 Formyl transferase
6130 PF13181 Tetratricopeptide repeat
6091 PF13360 PQQ-like domain
6085 PF13385 Concanavalin A-like lectin/glucanases superfamily
6074 PF00764 Arginosuccinate synthase
6061 PF13614 AAA domain
6046 PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
6025 PF01810 LysE type translocator
6022 PF01212 Beta-eliminating lyase
6005 PF03109 ABC1 atypical kinase-like domain
6001 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain
6000 PF13419 Haloacid dehalogenase-like hydrolase
5997 PF00282 Pyridoxal-dependent decarboxylase conserved domain
5991 PF00587 tRNA synthetase class II core domain (G, H, P, S and T)
5990 PF06253 Trimethylamine methyltransferase (MTTB)
5960 PF01381 Helix-turn-helix
5957 PF00732 GMC oxidoreductase
5930 PF03989 DNA gyrase C-terminal domain, beta-propeller
5930 PF01264 Chorismate synthase
5927 PF00300 Histidine phosphatase superfamily (branch 1)
5887 PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
5863 PF01977 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
5859 PF01694 Rhomboid family
5848 PF00118 TCP-1/cpn60 chaperonin family
5831 PF00154 recA bacterial DNA recombination protein
5829 PF00146 NADH dehydrogenase
5813 PF01808 AICARFT/IMPCHase bienzyme
5792 PF10609 NUBPL iron-transfer P-loop NTPase
5792 PF00344 SecY
5790 PF01208 Uroporphyrinogen decarboxylase (URO-D)
5713 PF17657 Bacterial DNA polymerase III alpha subunit finger domain
5695 PF13683 Integrase core domain
5688 PF03806 AbgT putative transporter family
5678 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
5645 PF02355 Protein export membrane protein
5638 PF01855 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg
5613 PF05362 Lon protease (S16) C-terminal proteolytic domain
5592 PF01406 tRNA synthetases class I (C) catalytic domain
5570 PF01458 SUF system FeS cluster assembly, SufBD
5554 PF01274 Malate synthase
5549 PF00515 Tetratricopeptide repeat
5546 PF02547 Queuosine biosynthesis protein
5517 PF01063 Amino-transferase class IV
5502 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase
5463 PF03764 Elongation factor G, domain IV
5455 PF01244 Membrane dipeptidase (Peptidase family M19)
5444 PF03796 DnaB-like helicase C terminal domain
5431 PF04909 Amidohydrolase
5424 PF08447 PAS fold
5418 PF00070 Pyridine nucleotide-disulphide oxidoreductase
5398 PF13347 MFS/sugar transport protein
5387 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
5379 PF01653 NAD-dependent DNA ligase adenylation domain
5342 PF00881 Nitroreductase family
5338 PF08264 Anticodon-binding domain of tRNA ligase
5330 PF01343 Peptidase family S49
5328 PF01026 TatD related DNase
5311 PF01494 FAD binding domain
5311 PF00085 Thioredoxin
5305 PF00665 Integrase core domain
5299 PF07719 Tetratricopeptide repeat
5293 PF00111 2Fe-2S iron-sulfur cluster binding domain
5291 PF00480 ROK family
5290 PF03061 Thioesterase superfamily
5290 PF02405 Permease MlaE
5264 PF00586 AIR synthase related protein, N-terminal domain
5255 PF00289 Biotin carboxylase, N-terminal domain
5253 PF03349 Outer membrane protein transport protein (OMPP1/FadL/TodX)
5251 PF02875 Mur ligase family, glutamate ligase domain
5239 PF02350 UDP-N-acetylglucosamine 2-epimerase
5227 PF01625 Peptide methionine sulfoxide reductase
5224 PF06418 CTP synthase N-terminus
5215 PF11751 Type IX secretion system membrane protein PorP/SprF
5204 PF02472 Biopolymer transport protein ExbD/TolR
5203 PF00994 Probable molybdopterin binding domain
5197 PF13377 Periplasmic binding protein-like domain
5197 PF03050 Transposase IS66 family
5187 PF02353 Mycolic acid cyclopropane synthetase
5162 PF06965 Na+/H+ antiporter 1
5155 PF10431 C-terminal, D2-small domain, of ClpB protein
5155 PF00950 ABC 3 transport family
5139 PF01627 Hpt domain
5136 PF01515 Phosphate acetyl/butaryl transferase
5114 PF04898 Glutamate synthase central domain
5111 PF03176 MMPL family
5103 PF00490 Delta-aminolevulinic acid dehydratase
5100 PF08668 HDOD domain
5100 PF00216 Bacterial DNA-binding protein
5096 PF01261 Xylose isomerase-like TIM barrel
5078 PF13302 Acetyltransferase (GNAT) domain
5064 PF00675 Insulinase (Peptidase family M16)
5060 PF13537 Glutamine amidotransferase domain
5053 PF12831 FAD dependent oxidoreductase
5040 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain
5040 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit
5017 PF01968 Hydantoinase/oxoprolinase
5002 PF08352 Oligopeptide/dipeptide transporter, C-terminal region
5000 PF00370 FGGY family of carbohydrate kinases, N-terminal domain
4982 PF01479 S4 domain
4977 PF00773 RNB domain
4970 PF02562 PhoH-like protein
4969 PF01168 Alanine racemase, N-terminal domain
4957 PF02880 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
4953 PF01882 Protein of unknown function DUF58
4942 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
4930 PF19289 PmbA/TldA metallopeptidase C-terminal domain
4920 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
4914 PF13570 PQQ-like domain
4912 PF00204 DNA gyrase B
4909 PF00872 Transposase, Mutator family
4909 PF00574 Clp protease
4908 PF01300 Telomere recombination
4882 PF05721 Phytanoyl-CoA dioxygenase (PhyH)
4872 PF05221 S-adenosyl-L-homocysteine hydrolase
4868 PF01409 tRNA synthetases class II core domain (F)
4868 PF00156 Phosphoribosyl transferase domain
4860 PF01964 Radical SAM ThiC family
4845 PF00929 Exonuclease
4830 PF07631 Protein of unknown function (DUF1592)
4825 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit
4816 PF03023 Lipid II flippase MurJ
4816 PF01751 Toprim domain
4809 PF04820 Tryptophan halogenase
4796 PF00962 Adenosine deaminase
4789 PF00702 haloacid dehalogenase-like hydrolase
4761 PF01507 Phosphoadenosine phosphosulfate reductase family
4740 PF07593 ASPIC and UnbV
4737 PF02668 Taurine catabolism dioxygenase TauD, TfdA family
4728 PF03160 Calx-beta domain
4691 PF17820 PDZ domain
4652 PF08811 Protein of unknown function (DUF1800)
4649 PF01795 MraW methylase family
4648 PF02540 NAD synthase
4645 PF00343 Carbohydrate phosphorylase
4643 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
4640 PF03144 Elongation factor Tu domain 2
4635 PF07885 Ion channel
4629 PF01070 FMN-dependent dehydrogenase
4626 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase
4624 PF03129 Anticodon binding domain
4621 PF00591 Glycosyl transferase family, a/b domain
4588 PF03739 Lipopolysaccharide export system permease LptF/LptG
4586 PF02910 Fumarate reductase flavoprotein C-term
4584 PF01434 Peptidase family M41
4582 PF13177 DNA polymerase III, delta subunit
4575 PF00472 RF-1 domain
4572 PF02080 TrkA-C domain
4545 PF03150 Di-haem cytochrome c peroxidase
4544 PF01066 CDP-alcohol phosphatidyltransferase
4540 PF05345 Putative Ig domain
4539 PF10502 Signal peptidase, peptidase S26
4537 PF07883 Cupin domain
4533 PF01595 Cyclin M transmembrane N-terminal domain
4518 PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases
4517 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain
4509 PF00308 Bacterial dnaA protein
4496 PF01037 Lrp/AsnC ligand binding domain
4495 PF00871 Acetokinase family
4490 PF01578 Cytochrome C assembly protein
4489 PF00805 Pentapeptide repeats (8 copies)
4480 PF02092 Glycyl-tRNA synthetase beta subunit
4476 PF02548 Ketopantoate hydroxymethyltransferase
4473 PF00226 DnaJ domain
4466 PF01699 Sodium/calcium exchanger protein
4463 PF00860 Permease family
4457 PF01103 Omp85 superfamily domain
4443 PF01433 Peptidase family M1 domain
4435 PF01925 Sulfite exporter TauE/SafE
4424 PF00121 Triosephosphate isomerase
4422 PF01761 3-dehydroquinate synthase
4418 PF01180 Dihydroorotate dehydrogenase
4414 PF08282 haloacid dehalogenase-like hydrolase
4409 PF04551 GcpE protein
4401 PF11376 Protein of unknown function (DUF3179)
4401 PF04879 Molybdopterin oxidoreductase Fe4S4 domain
4399 PF05199 GMC oxidoreductase
4399 PF01970 Tripartite tricarboxylate transporter TctA family
4383 PF00762 Ferrochelatase
4377 PF02901 Pyruvate formate lyase-like
4375 PF01695 IstB-like ATP binding protein
4364 PF01545 Cation efflux family
4359 PF08238 Sel1 repeat
4342 PF01594 AI-2E family transporter
4323 PF00318 Ribosomal protein S2
4316 PF07589 PEP-CTERM motif
4305 PF02965 Vitamin B12 dependent methionine synthase, activation domain
4304 PF00899 ThiF family
4301 PF04539 Sigma-70 region 3
4299 PF02785 Biotin carboxylase C-terminal domain
4298 PF07244 Surface antigen variable number repeat
4291 PF00728 Glycosyl hydrolase family 20, catalytic domain
4284 PF03279 Bacterial lipid A biosynthesis acyltransferase
4281 PF01738 Dienelactone hydrolase family
4279 PF04069 Substrate binding domain of ABC-type glycine betaine transport system
4260 PF00083 Sugar (and other) transporter
4257 PF13487 HD domain
4250 PF01715 IPP transferase
4243 PF00834 Ribulose-phosphate 3 epimerase family
4232 PF02386 Cation transport protein
4229 PF00231 ATP synthase
4223 PF03710 Glutamate-ammonia ligase adenylyltransferase
4221 PF01144 Coenzyme A transferase
4216 PF00953 Glycosyl transferase family 4
4213 PF00149 Calcineurin-like phosphoesterase
4202 PF01734 Patatin-like phospholipase
4201 PF00669 Bacterial flagellin N-terminal helical region
4199 PF03007 Wax ester synthase-like Acyl-CoA acyltransferase domain
4197 PF12146 Serine aminopeptidase, S33
4194 PF17863 AAA lid domain
4194 PF12804 MobA-like NTP transferase domain
4190 PF00941 FAD binding domain in molybdopterin dehydrogenase
4169 PF04998 RNA polymerase Rpb1, domain 5
4162 PF03143 Elongation factor Tu C-terminal domain
4158 PF01259 SAICAR synthetase
4146 PF01243 Pyridoxamine 5'-phosphate oxidase
4137 PF00232 Glycosyl hydrolase family 1
4132 PF03600 Citrate transporter
4127 PF02469 Fasciclin domain
4103 PF04986 Putative transposase
4089 PF01522 Polysaccharide deacetylase
4077 PF01676 Metalloenzyme superfamily
4071 PF12770 CHAT domain
4070 PF13247 4Fe-4S dicluster domain
4066 PF13417 Glutathione S-transferase, N-terminal domain
4050 PF13585 CHU_C Type IX secretion signal domain
4050 PF01584 CheW-like domain
4048 PF10459 Peptidase S46
4041 PF00926 3,4-dihydroxy-2-butanone 4-phosphate synthase
4030 PF01790 Prolipoprotein diacylglyceryl transferase
4027 PF03308 Methylmalonyl Co-A mutase-associated GTPase MeaB
4023 PF00694 Aconitase C-terminal domain
4022 PF01609 Transposase DDE domain
4022 PF01209 ubiE/COQ5 methyltransferase family
4017 PF00175 Oxidoreductase NAD-binding domain
4008 PF05222 Alanine dehydrogenase/PNT, N-terminal domain
4005 PF02934 GatB/GatE catalytic domain
4001 PF04851 Type III restriction enzyme, res subunit
4000 PF03331 UDP-3-O-acyl N-acetylglycosamine deacetylase
3994 PF00543 Nitrogen regulatory protein P-II
3988 PF00925 GTP cyclohydrolase II
3982 PF13519 von Willebrand factor type A domain
3982 PF00313 'Cold-shock' DNA-binding domain
3972 PF00939 Sodium:sulfate symporter transmembrane region
3970 PF07556 Protein of unknown function (DUF1538)
3957 PF01255 Putative undecaprenyl diphosphate synthase
3953 PF00923 Transaldolase/Fructose-6-phosphate aldolase
3952 PF13442 Cytochrome C oxidase, cbb3-type, subunit III
3949 PF02569 Pantoate-beta-alanine ligase
3939 PF02384 N-6 DNA Methylase
3936 PF00393 6-phosphogluconate dehydrogenase, C-terminal domain
3933 PF12848 ABC transporter
3925 PF02401 LytB protein
3923 PF05157 Type II secretion system (T2SS), protein E, N-terminal domain
3923 PF00756 Putative esterase
3919 PF05593 RHS Repeat
3917 PF03949 Malic enzyme, NAD binding domain
3916 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain
3916 PF00391 PEP-utilising enzyme, mobile domain
3909 PF03054 tRNA methyl transferase HUP domain
3903 PF02684 Lipid-A-disaccharide synthetase
3901 PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region
3893 PF13180 PDZ domain
3890 PF02874 ATP synthase alpha/beta family, beta-barrel domain
3888 PF02811 PHP domain
3885 PF03009 Glycerophosphoryl diester phosphodiesterase family
3881 PF04997 RNA polymerase Rpb1, domain 1
3877 PF13292 1-deoxy-D-xylulose-5-phosphate synthase
3876 PF03486 HI0933-like protein
3864 PF01467 Cytidylyltransferase-like
3861 PF08448 PAS fold
3860 PF02445 Quinolinate synthetase A protein
3855 PF00817 impB/mucB/samB family
3851 PF16327 Cytochrome c-type biogenesis protein CcmF C-terminal
3841 PF02543 Carbamoyltransferase N-terminus
3836 PF00488 MutS domain V
3832 PF00239 Resolvase, N terminal domain
3831 PF17871 AAA lid domain
3829 PF01799 [2Fe-2S] binding domain
3822 PF03606 C4-dicarboxylate anaerobic carrier
3821 PF14492 Elongation Factor G, domain III
3820 PF01116 Fructose-bisphosphate aldolase class-II
3817 PF01012 Electron transfer flavoprotein domain
3796 PF01583 Adenylylsulphate kinase
3794 PF02545 Maf-like protein
3793 PF00209 Sodium:neurotransmitter symporter family
3779 PF13188 PAS domain
3773 PF02517 Type II CAAX prenyl endopeptidase Rce1-like
3773 PF00902 Sec-independent protein translocase protein (TatC)
3770 PF02774 Semialdehyde dehydrogenase, dimerisation domain
3766 PF00303 Thymidylate synthase
3757 PF00390 Malic enzyme, N-terminal domain
3748 PF01580 FtsK/SpoIIIE family
3744 PF01612 3'-5' exonuclease
3739 PF07977 FabA-like domain
3728 PF02219 Methylenetetrahydrofolate reductase
3720 PF10531 SLBB domain
3718 PF01061 ABC-2 type transporter
3706 PF01136 Peptidase family U32
3704 PF13091 PLD-like domain
3704 PF02861 Clp amino terminal domain, pathogenicity island component
3704 PF01327 Polypeptide deformylase
3693 PF07662 Na+ dependent nucleoside transporter C-terminus
3692 PF08534 Redoxin
3685 PF00654 Voltage gated chloride channel
3681 PF01384 Phosphate transporter family
3677 PF00290 Tryptophan synthase alpha chain
3664 PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
3664 PF01709 Transcriptional regulator
3654 PF06934 Fatty acid cis/trans isomerase (CTI)
3646 PF00850 Histone deacetylase domain
3643 PF12704 MacB-like periplasmic core domain
3642 PF08442 ATP-grasp domain
3627 PF02782 FGGY family of carbohydrate kinases, C-terminal domain
3620 PF01758 Sodium Bile acid symporter family
3620 PF00930 Dipeptidyl peptidase IV (DPP IV) N-terminal region
3593 PF01225 Mur ligase family, catalytic domain
3592 PF03740 Pyridoxal phosphate biosynthesis protein PdxJ
3587 PF00596 Class II Aldolase and Adducin N-terminal domain
3580 PF13507 CobB/CobQ-like glutamine amidotransferase domain
3577 PF00750 tRNA synthetases class I (R)
3573 PF04290 Tripartite ATP-independent periplasmic transporters, DctQ component
3565 PF16868 NMT1-like family
3560 PF01527 Transposase
3560 PF00742 Homoserine dehydrogenase
3558 PF03702 Anhydro-N-acetylmuramic acid kinase
3557 PF11898 Domain of unknown function (DUF3418)
3543 PF13602 Zinc-binding dehydrogenase
3541 PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
3540 PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
3533 PF01078 Magnesium chelatase, subunit ChlI
3526 PF02739 5'-3' exonuclease, N-terminal resolvase-like domain
3525 PF13374 Tetratricopeptide repeat
3522 PF02541 Ppx/GppA phosphatase family
3521 PF07627 Protein of unknown function (DUF1588)
3508 PF08309 LVIVD repeat
3506 PF01436 NHL repeat
3499 PF02673 Bacitracin resistance protein BacA
3493 PF00089 Trypsin
3490 PF05496 Holliday junction DNA helicase RuvB P-loop domain
3484 PF08545 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
3481 PF01227 GTP cyclohydrolase I
3479 PF08335 GlnD PII-uridylyltransferase
3477 PF13603 Leucyl-tRNA synthetase, Domain 2
3475 PF13439 Glycosyltransferase Family 4
3475 PF03717 Penicillin-binding Protein dimerisation domain
3474 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
3466 PF04321 RmlD substrate binding domain
3459 PF03544 Gram-negative bacterial TonB protein C-terminal
3448 PF00359 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
3441 PF05378 Hydantoinase/oxoprolinase N-terminal region
3441 PF02690 Na+/Pi-cotransporter
3432 PF00356 Bacterial regulatory proteins, lacI family
3432 PF00183 Hsp90 protein
3432 PF00140 Sigma-70 factor, region 1.2
3430 PF00218 Indole-3-glycerol phosphate synthase
3425 PF07859 alpha/beta hydrolase fold
3425 PF07516 SecA Wing and Scaffold domain
3422 PF17757 UvrB interaction domain
3420 PF01118 Semialdehyde dehydrogenase, NAD binding domain
3419 PF20434 BD-FAE
3416 PF03616 Sodium/glutamate symporter
3413 PF04127 DNA / pantothenate metabolism flavoprotein
3403 PF01263 Aldose 1-epimerase
3385 PF01914 MarC family integral membrane protein
3384 PF00768 D-alanyl-D-alanine carboxypeptidase
3382 PF01312 FlhB HrpN YscU SpaS Family
3380 PF05114 Protein of unknown function (DUF692)
3356 PF07478 D-ala D-ala ligase C-terminus
3353 PF01556 DnaJ C terminal domain
3352 PF08298 PrkA AAA domain
3350 PF01593 Flavin containing amine oxidoreductase
3338 PF00011 Hsp20/alpha crystallin family
3336 PF01075 Glycosyltransferase family 9 (heptosyltransferase)
3326 PF01138 3' exoribonuclease family, domain 1
3325 PF02492 CobW/HypB/UreG, nucleotide-binding domain
3324 PF02504 Fatty acid synthesis protein
3322 PF02446 4-alpha-glucanotransferase
3322 PF00889 Elongation factor TS
3321 PF02441 Flavoprotein
3320 PF03734 L,D-transpeptidase catalytic domain
3307 PF07714 Protein tyrosine and serine/threonine kinase
3303 PF08450 SMP-30/Gluconolactonase/LRE-like region
3300 PF11617 Putative metal-binding motif
3299 PF00919 Uncharacterized protein family UPF0004
3292 PF03483 B3/4 domain
3292 PF02754 Cysteine-rich domain
3290 PF13428 Tetratricopeptide repeat
3281 PF03352 Methyladenine glycosylase
3280 PF02423 Ornithine cyclodeaminase/mu-crystallin family
3280 PF01619 Proline dehydrogenase
3271 PF02142 MGS-like domain
3268 PF09317 Acyl-CoA dehydrogenase, C-terminal, bacterial type
3268 PF02646 RmuC family
3261 PF01379 Porphobilinogen deaminase, dipyromethane cofactor binding domain
3260 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
3258 PF02348 Cytidylyltransferase
3250 PF01746 tRNA (Guanine-1)-methyltransferase
3245 PF12706 Beta-lactamase superfamily domain
3244 PF08669 Glycine cleavage T-protein C-terminal barrel domain
3241 PF14691 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
3241 PF03453 MoeA N-terminal region (domain I and II)
3226 PF13328 HD domain
3226 PF04293 SpoVR like protein
3219 PF13715 CarboxypepD_reg-like domain
3219 PF00078 Reverse transcriptase (RNA-dependent DNA polymerase)
3218 PF02074 Carboxypeptidase Taq (M32) metallopeptidase
3216 PF01297 Zinc-uptake complex component A periplasmic
3214 PF13847 Methyltransferase domain
3210 PF01112 Asparaginase
3205 PF01175 Urocanase Rossmann-like domain
3203 PF07991 Acetohydroxy acid isomeroreductase, NADPH-binding domain
3195 PF04166 Pyridoxal phosphate biosynthetic protein PdxA
3195 PF01139 tRNA-splicing ligase RtcB
3184 PF17131 Outer membrane lipoprotein-sorting protein
3183 PF00374 Nickel-dependent hydrogenase
3179 PF13522 Glutamine amidotransferase domain
3176 PF00487 Fatty acid desaturase
3170 PF17831 Pyruvate dehydrogenase E1 component middle domain
3169 PF02627 Carboxymuconolactone decarboxylase family
3168 PF07729 FCD domain
3162 PF17760 UvrA interaction domain
3161 PF02481 DNA recombination-mediator protein A
3160 PF13242 HAD-hyrolase-like
3156 PF07238 PilZ domain
3149 PF01641 SelR domain
3142 PF04952 Succinylglutamate desuccinylase / Aspartoacylase family
3141 PF06325 Ribosomal protein L11 methyltransferase (PrmA)
3140 PF06429 Flagellar basal body rod FlgEFG protein C-terminal
3138 PF00177 Ribosomal protein S7p/S5e
3135 PF02113 D-Ala-D-Ala carboxypeptidase 3 (S13) family
3134 PF01743 Poly A polymerase head domain
3131 PF02119 Flagellar P-ring protein
3127 PF01323 DSBA-like thioredoxin domain
3121 PF06742 Protein of unknown function (DUF1214)
3102 PF13549 ATP-grasp domain
3101 PF17392 Urocanase C-terminal domain
3099 PF01451 Low molecular weight phosphotyrosine protein phosphatase
3091 PF13412 Winged helix-turn-helix DNA-binding
3084 PF16861 Carbamoyltransferase C-terminus
3084 PF02606 Tetraacyldisaccharide-1-P 4'-kinase
3084 PF00213 ATP synthase delta (OSCP) subunit
3077 PF03772 Competence protein
3076 PF06974 WS/DGAT C-terminal domain
3075 PF05175 Methyltransferase small domain
3074 PF00677 Lumazine binding domain
3072 PF12796 Ankyrin repeats (3 copies)
3063 PF02879 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
3061 PF01725 Ham1 family
3056 PF13411 MerR HTH family regulatory protein
3053 PF13620 Carboxypeptidase regulatory-like domain
3052 PF07971 Glycosyl hydrolase family 92
3044 PF01558 Pyruvate ferredoxin/flavodoxin oxidoreductase
3043 PF00210 Ferritin-like domain
3038 PF06450 Bacterial Na+/H+ antiporter B (NhaB)
3037 PF00166 Chaperonin 10 Kd subunit
3035 PF01520 N-acetylmuramoyl-L-alanine amidase
3033 PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
3033 PF01654 Cytochrome bd terminal oxidase subunit I
3032 PF03190 Protein of unknown function, DUF255
3029 PF13520 Amino acid permease
3027 PF05896 Na(+)-translocating NADH-quinone reductase subunit A (NQRA)
3027 PF00857 Isochorismatase family
3021 PF18884 Bacterial TSP3 repeat
3020 PF13406 Transglycosylase SLT domain
3020 PF06537 Di-haem oxidoreductase, putative peroxidase
3020 PF01148 Cytidylyltransferase family
3020 PF00549 CoA-ligase
3019 PF00436 Single-strand binding protein family
3018 PF08459 UvrC RNAse H endonuclease domain
3018 PF03313 Serine dehydratase alpha chain
3017 PF05544 Proline racemase
3014 PF00368 Hydroxymethylglutaryl-coenzyme A reductase
3012 PF02899 Phage integrase, N-terminal SAM-like domain
3012 PF01872 RibD C-terminal domain
3008 PF02773 S-adenosylmethionine synthetase, C-terminal domain
3004 PF14833 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
3004 PF00174 Oxidoreductase molybdopterin binding domain
3003 PF03977 Na+-transporting oxaloacetate decarboxylase beta subunit
3002 PF04073 Aminoacyl-tRNA editing domain
2999 PF00398 Ribosomal RNA adenine dimethylase
2989 PF00460 Flagella basal body rod protein
2985 PF03950 tRNA synthetases class I (E and Q), anti-codon binding domain
2983 PF02146 Sir2 family
2982 PF01081 KDPG and KHG aldolase
2981 PF04116 Fatty acid hydroxylase
2979 PF01493 GXGXG motif
2977 PF04264 YceI-like domain
2974 PF03222 Tryptophan/tyrosine permease family
2973 PF03668 P-loop ATPase protein family
2973 PF02096 60Kd inner membrane protein
2966 PF00462 Glutaredoxin
2961 PF01022 Bacterial regulatory protein, arsR family
2959 PF13616 PPIC-type PPIASE domain
2959 PF01043 SecA preprotein cross-linking domain
2949 PF04397 LytTr DNA-binding domain
2947 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain
2946 PF00119 ATP synthase A chain
2942 PF13795 HupE / UreJ protein
2941 PF02696 Protein adenylyltransferase SelO
2940 PF01765 Ribosome recycling factor
2934 PF00246 Zinc carboxypeptidase
2931 PF01597 Glycine cleavage H-protein
2930 PF03328 HpcH/HpaI aldolase/citrate lyase family
2928 PF08323 Starch synthase catalytic domain
2926 PF05690 Thiazole biosynthesis protein ThiG
2924 PF02310 B12 binding domain
2923 PF17759 Phenylalanyl tRNA synthetase beta chain CLM domain
2923 PF01895 PhoU domain
2922 PF01336 OB-fold nucleic acid binding domain

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