Constraint Based Analysis#
In this notebook, we are going to discuss some basics of CBA from their mathematical, theoretical and biological perspective.
Overflow metabolism is caused by two growth‑limiting constraints#
Literature
Overflow metabolism in Escherichia coli results from efficient proteome allocation.
The authors assume that the yield of energy per carbon molecule is higher for respiration than for fermentation: \(n{_r} > n{_f}\), but that fermentation is more proteome-efficient: \(\epsilon{_f} > \epsilon{_r}\).